vascular permeability — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8844	Diflapolin		Others , FLAP , Epoxide Hydrolase
	Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity.		Others , FLAP , Epoxide Hydrolase
T2456	Tivozanib	AV-951,KRN951	VEGFR , PDGFR , Ephrin Receptor
	Tivozanib (KRN951) is an orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities.		VEGFR , PDGFR , Ephrin Receptor
T5194	SPHINX31		Serine/threonin kinase
	SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50: 5.9 nM).		Serine/threonin kinase
T63505	Tivozanib hydrochloride hydrate
	Tivozanib hydrochloride hydrate is a selective, potent, orally active VEGFR tyrosine kinase inhibitor that acts on VEGFR-1 (IC50: 0.21 nM), VEGFR-2 (IC50: 0.16 nM), and VEGFR-3 (IC50: 0.24 nM). Tivozanib hydrochloride hy...
T5S1889	Yunaconitine	Guayewuanine B	Others
	1. Yunaconitine (Guayewuanine B) has anti-inflammatory and analgesic actions. 2. Yunaconitine was shown to have anti-thermic effect in pyrexial rats when administered orally at a dose of 5 μg/kg. 3. Yunaconitine shows po...		Others
T2520	Desloratadine	Sch34117,NSC 675447	Endogenous Metabolite , Histamine Receptor
	Desloratadine (Sch34117) is a long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smoot...		Endogenous Metabolite , Histamine Receptor
T16344	NS-2028		Others , Guanylate cyclase
	NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used in the research of nitric oxide signaling pathways. NS-2028...		Others , Guanylate cyclase
T6529	Halobetasol propionate	Halobetasol Propionate,Ulobetasol propionate,BMY-30056,CGP-14458	Phospholipase
	Halobetasol propionate (BMY-30056) is the propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses acr...		Phospholipase
T2403	Bromfenac sodium hydrate	Bromfenac sodium,Bromfenac monosodium salt sesquihydrate	COX
	Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and anti-inflammatory activities. Upon ophthalmic admi...		COX
T3979	Emedastine	LY188695,Emadine	Histamine Receptor
	Emedastine (LY188695) is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its...		Histamine Receptor
T32681	Leukotriene F-4 sulfone	Ltf4 sulfone
	Leukotriene F-4 sulfone induces vascular permeability changes.
T26491	AA 2379	AA2379,AA-2379
	AA 2379, an anti inflammatory agent, inhibits the vascular permeability induced by histamine, serotonin, and bradykinin. It also has some analgesic activity.
TN5575	Coronarin D methyl ether
	Coronarin D methyl ether has inhibitory effects on the increase in vascular permeability, nitric oxide production, and inducible nitric oxide synthase induction.
T21388	Emedastine Difumarate	Rapimine,DSSTox_CID_26911,AL-3432A,KB-2413,Emedastine fumarate,KB 2413
	Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of hist...
T71722	Angiogenesis inhibitor BT2
	Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, ang...
T37261	14,15-Leukotriene D4	14,15-Leukotriene D4
	14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 ...
T76895	Abicipar pegol
	Abicipar pegol (AGN-150998, MP0112), an anti-VEGF DARPin molecule, represents a novel class of small ankyrin repeat domain-containing proteins designed for high specificity and affinity targeting. This compound is adept ...
T37620	Leukotriene C4 methyl ester
	Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular met...
T70906	EHT-6706
	EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more th...
T77089	Mirococept
	Mirococept (APT070), an antibody designed to target the complement system components C3b/C4b and act as a membrane-localizing C3 convertase inhibitor, effectively diminishes the release of C-peptide and pro-inflammatory ...